Summary
Princeton scientists describe a more efficient prime editor. The new system uses a modified version of the protein element of CRISPR/Cas9 and a ribonucleic acid (RNA) molecule called a pegRNA. In this way, prime editors "write" exact sequences into targeted DNA.
"This work is a beautiful example of how deeply probing the inner workings of cells can lead to unexpected insights," Bauer says. Researchers also found that PE7 can also enhance prime editing efficiencies in therapeutically relevant cell types. "This work... is a great example of the potential of this technology," Bauer adds.
